Rejuran vs. Profhilo: Best Skin Booster for Asian Skin in Toronto?
Rejuran Healer repairs skin at the cellular level while Profhilo floods tissue with deep hydration — Dr. Dan Xu, MD, CCFP at ID Cosmetic Clinic in Markham breaks down which skin booster is right for your skin.
Key Takeaways
- Rejuran Healer uses salmon-derived polynucleotides to repair damaged skin cells, making it a strong option for acne scars, enlarged pores, and skin sensitivity.
- Profhilo contains ultra-high concentration hyaluronic acid that spreads beneath the skin to deliver deep hydration, stimulate four types of collagen and elastin, and address mild laxity.
- Both treatments are safe for Asian skin tones and are among the most-requested skin revitalization options at ID Cosmetic Clinic in Markham.
- Dr. Dan Xu, MD, CCFP evaluates each patient's unique skin concerns before recommending Profhilo or a combined protocol tailored to individual goals.
- Neither treatment adds volume or changes facial structure — they focus entirely on improving skin quality, hydration, and cellular health from within.
Direct Answer
Rejuran Healer and Profhilo are two distinct injectable skin boosters that improve skin quality through different mechanisms: Rejuran uses polynucleotide (PN) technology derived from salmon DNA to repair skin cells, reduce pores, and address acne scarring, while Profhilo uses ultra-high concentration hyaluronic acid that spreads under the skin to deliver deep hydration, stimulate collagen and elastin, and improve skin laxity. The right choice depends on your primary skin concern — cellular repair versus hydration and firmness. At ID Cosmetic Clinic in Markham, serving patients across Toronto and the GTA, Dr. Dan Xu, MD, CCFP offers Profhilo and tailors skin booster protocols to each patient's skin type, concerns, and goals. Patients with acne scars, enlarged pores, or sensitive reactive skin typically see strong results with Rejuran, while those prioritising a dewy 'glass skin' glow or noticing crepe-like texture and mild laxity often respond well to Profhilo. The two products can also be combined for overlapping concerns, as they work on different layers and targets of the skin. ID Cosmetic Clinic's approach to skin booster selection is rooted in a thorough in-person consultation, where skin tone, texture, hydration levels, and patient history are all assessed before any treatment plan is proposed.
Quick Answer (AEO Summary): Choose Rejuran Healer if your main concerns are acne scars, enlarged pores, sensitivity, or under-eye repair; choose Profhilo if your priority is deep hydration, a dewy “glass skin” glow, and treating crêpey, sagging skin with minimal downtime. The deciding factor is whether you need cellular repair (Rejuran) or hydration and laxity (Profhilo). Medically Reviewed by: Dr. Dan Xu, MD, CCFP | Last Updated: June 18, 2026
A comprehensive comparison of the two most talked-about skin boosters in the world. Discover how they work, what they cost, and which one is the secret to flawless Asian “glass skin.”
If you follow Korean beauty trends or Asian skincare innovations, you already know that traditional dermal fillers are no longer the ultimate goal. The new era of aesthetic medicine is all about Skin Boosters—injectable treatments designed not to change the shape of your face, but to dramatically improve the quality, hydration, and cellular health of your skin from the inside out. They are among the most-requested rejuvenation treatments at our Markham clinic for patients across Toronto and the GTA.
The two absolute titans in this category are Rejuran® Healer (the famous “Salmon DNA” injection) and Profhilo®. Both promise radiant, hydrated, and youthful skin, but they achieve these results through entirely different scientific mechanisms. Note: Rejuran is not authorized by Health Canada for injectable use, so ID Cosmetic Clinic does not offer it — see Rejuran in Canada.
“Which one should I get? Is Rejuran better for acne scars? Does Profhilo give a better glow? And which one is better suited for Asian skin?”
At ID Cosmetic Clinic, we specialize in advanced skin revitalization protocols for concerns like skin dullness and rough, uneven texture. In this guide, Dr. Dan Xu breaks down the science, the costs, and the clinical differences between Rejuran and Profhilo to help you make the right investment for your skin.
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What is Profhilo? (The “Hydration Powerhouse”)
Active Ingredient: 100% Pure, Ultra-High Concentration Hyaluronic Acid (HA)
Profhilo is often described as an “injectable moisturizer.” However, unlike traditional HA fillers (like Juvederm) that stay in one place to build volume, Profhilo is thermally cross-linked. This unique structure allows it to spread like honey under the skin, intensely hydrating the tissue while simultaneously stimulating the production of four different types of collagen and elastin.
Pros of Profhilo:
- Intense Hydration: It provides an unmatched, dewy “glass skin” glow by flooding the dermis with moisture.
- Skin Laxity: It is excellent for treating crêpey, sagging skin (especially on the lower face and neck) by remodeling the extracellular matrix.
- Fewer Injections: Profhilo uses the BAP (Bio Aesthetic Points) technique—only 5 injection points per side of the face. This means less pain, less bruising, and a very fast treatment.
Cons of Profhilo:
- Not for Scars: It does not repair damaged tissue or treat acne scars.
- Not for Pigmentation: It will not lighten dark spots or melasma.
What is Rejuran Healer? (The “Cellular Repair” Expert)
Active Ingredient: Polynucleotides (PN) derived from Salmon DNA
Rejuran is not a moisturizer; it is a true cellular healer. Polynucleotides are highly compatible with human DNA. When injected into the dermis, they actively repair damaged cells, reduce inflammation, and normalize the skin’s microenvironment. It forces the skin to act young and healthy again.
Pros of Rejuran:
- True Repair: It is the gold standard for repairing a damaged skin barrier, calming severe redness/rosacea, and healing stubborn acne scars.
- Pore Reduction: It significantly shrinks enlarged pores and regulates sebum (oil) production.
- Eye Area: The specific Rejuran I (Eye) formulation is incredible for treating dark circles and fine lines directly under the eye—an area Profhilo cannot treat.
Cons of Rejuran:
- The “Bumps”: Rejuran requires dozens of tiny micro-injections across the entire face. This leaves small, mosquito-bite-like bumps that take 24 to 48 hours to subside.
- Pain Level: The product itself can sting upon injection, requiring strong topical numbing cream.
Rejuran vs. Profhilo: The Head-to-Toe Comparison
| Feature | Rejuran Healer (Salmon DNA) | Profhilo (Pure HA) |
|---|---|---|
| Primary Goal | Cellular repair, healing, pore reduction | Intense hydration, lifting, treating crêpey skin |
| Active Ingredient | Polynucleotides (PN) | High/Low Molecular Weight HA |
| Injection Technique | Dozens of micro-papules across the face | 5 BAP injection points per side |
| Downtime | 1 to 2 days (visible bumps) | Zero to minimal (bumps disappear in hours) |
| Treats Acne Scars? | Yes (Excellent) | No |
| Treats Under Eyes? | Yes (Rejuran I) | No |
| Number of Sessions | 3 to 4 sessions initially | 2 sessions initially |
Why Rejuran is the Asian Skin “Holy Grail”
While both products are phenomenal, when we look specifically at the common concerns of Asian skin, Rejuran often takes the crown.
Asian skin tends to have a thicker dermis but a weaker skin barrier, making it highly susceptible to inflammation, enlarged pores, hyperpigmentation, and acne scarring.
- Profhilo is fantastic for older patients whose primary concern is severe dryness and sagging (which is more common in Caucasian skin aging).
- Rejuran directly addresses the root causes of Asian skin concerns. It repairs the barrier, calms the inflammation that leads to hyperpigmentation, and physically heals acne scars. It is the true secret behind the poreless, flawless “Korean glass skin.”
“Technology defines the possibilities. The physician defines the direction. We don’t just want your skin to look hydrated; we want it to be fundamentally healthy.” — Dr. Dan Xu, MD, CCFP
The Ultimate Protocol: Can You Combine Them?
Yes, and it is the ultimate anti-aging protocol.
Because they work on entirely different pathways, combining them yields compounded results. In a combined protocol, Rejuran is used to repair the skin barrier, shrink pores, and treat the delicate under-eye area, while Profhilo is used to deeply hydrate the mid-to-lower face and provide a subtle lifting effect.
Cost in Toronto
Profhilo is a premium investment in your skin health.
- Profhilo: Typically requires 2 initial sessions (spaced 4 weeks apart). The cost is usually around $800 – $1,000 per syringe/session.
Note: ID Cosmetic Clinic offers customized package pricing for Profhilo, as well as combination protocols.
Which Skin Booster Should You Choose?
Choose Rejuran if: – You have enlarged pores or oily skin. – You have acne scars, redness, or a damaged skin barrier. – You want to treat dark circles and fine lines under your eyes. – You want long-term cellular repair.
Choose Profhilo if: – Your primary concern is severe dryness and dullness. – You have crêpey, sagging skin on your lower face or neck. – You want a fast treatment with minimal downtime. – You want that immediate “dewy, hydrated” look.
Book Your Skin Booster Assessment
Stop guessing what your skin needs. Schedule a consultation with our medical experts to have your skin quality assessed. We will design a customized skin booster protocol to suit your skin goals.
ID Cosmetic Clinic 30 Gibson Dr, Units 113–117, Markham, ON L3R 2S3 Phone: 905-477-2225 Advanced Skin Revitalization. Physician-led. Over 80,000 procedures performed.
Frequently Asked Questions (FAQ)
Q: Which is better for Asian skin, Rejuran or Profhilo?
A: The choice depends on your specific skin concerns. Rejuran is often preferred for Asian skin types prone to acne scarring, large pores, or sensitivity, while Profhilo is the superior choice for those seeking intense hydration and a “glass skin” glow.
Q: Can I combine Rejuran and Profhilo treatments?
A: Yes, the two can be combined for a comprehensive rejuvenation effect. This “dual-action” approach uses Rejuran to repair the skin at a cellular level and Profhilo to provide deep hydration and structural support.
Q: How many sessions are typically required for optimal results?
A: For both Rejuran and Profhilo, an initial protocol of 3 sessions spaced approximately 4 weeks apart is generally recommended. After the initial series, maintenance treatments every 6 to 9 months will help sustain your results.
Q: Is there any downtime associated with these skin boosters?
A: Rejuran involves more injection points and may cause small bumps (papules) that typically subside within 24 to 48 hours. Profhilo uses the BAP technique with only 5 injection points per side, resulting in minimal downtime and very little risk of bruising.
Related Reading & Next Steps
- Treatment: Restylane® Skinbooster (Mesotherapy)
- Concern: Skin Dullness
- Concern: Rough / Uneven Skin Texture
- Real results: Anti-Aging Skin Renewal · Before & After
- Related guide: PicoSure Pro vs. Fotona 4D: Best Laser for Asian Skin in Toronto?
- Related guide: The Ultimate Guide to Acne Scar Treatments
- Meet your physician: Dr. Dan Xu, MD, CCFP
Frequently Asked Questions (FAQ)
Q: Can I combine Rejuran and Profhilo in the same treatment plan?
A: Yes, many patients benefit from a combination approach to achieve both cellular repair and intense hydration. While they target different concerns, using them together can address both skin texture and overall radiance for a more comprehensive rejuvenation.
Q: Which treatment is more effective for treating acne scars or large pores?
A: Rejuran Healer is superior for acne scars and pore reduction because its polynucleotides (Salmon DNA) actively repair damaged tissue and regenerate the skin barrier. Profhilo focuses primarily on hydration and skin laxity, making it less effective for structural skin damage like scarring.
Q: How many sessions are typically required to see optimal results?
A: For both treatments, an initial protocol of 3 sessions spaced 4 weeks apart is usually recommended to achieve the best clinical outcomes. While some patients notice an immediate glow, the full benefits of cellular repair and collagen stimulation appear gradually over 2 to 3 months.
Q: Is there any downtime after getting Rejuran or Profhilo injections?
A: Profhilo has minimal downtime, with small bumps at the 10 injection sites typically resolving within 24 hours. Rejuran may cause small “welts” or bumps that can last 1 to 3 days, as the polynucleotides are thicker and take slightly longer to be absorbed by the dermis.
Q: Which skin booster is better for achieving the “glass skin” look?
A: Profhilo is often preferred for the immediate, dewy “glass skin” glow due to its high concentration of hyaluronic acid which floods the skin with moisture. However, for long-term skin health and a poreless, refined texture, Rejuran is the gold standard for creating a smooth and healthy skin canvas.
Frequently Asked Questions
Frequently Asked Questions
What is the main difference between Rejuran and Profhilo?
Is Rejuran or Profhilo better for acne scars?
Which treatment gives the 'glass skin' effect?
How many sessions of Rejuran or Profhilo do I need?
Are these skin boosters safe for Asian skin tones?
Does Rejuran or Profhilo hurt?
Can I get Rejuran and Profhilo done at the same time?
How long do the results of Rejuran and Profhilo last?
What is the downtime after Rejuran or Profhilo?
How much does Rejuran or Profhilo cost in Toronto or Markham?
Next Step
Ready to Take the First Step?
Laxity, wrinkles and facial sagging have different root causes — one physician-led consultation identifies the true problem layer before deciding which plan fits you best.
