Rejuran PDRN Treatment for Skin Rejuvenation and Repair

Medically reviewed by Dr. Dan Xu, M.D., CCFP — CPSO Licensed Physician, official Allergan/Juvéderm trainer in North America, and Founder & Medical Director of ID Cosmetic Clinic, Markham. Last updated June 2026.

“Which skin booster is best?” is one of the most common questions we hear in our Markham clinic, especially from patients who want better skin quality rather than a changed face. Rejuran, Profhilo and Skinvive are three of the most respected injectable skin boosters in the world right now — but they are built from different ingredients, work through different mechanisms, and suit different skin concerns and ages. This guide breaks down exactly how each one works, who it is for, what it feels like, how long results last, and what it costs in Toronto — so you walk into a consultation already knowing the right questions to ask.

This article is general information, not medical advice. A qualified physician should assess your skin in person before recommending any treatment.

Rejuran vs Profhilo vs Skinvive — at a glance

Prices vary by product, number of sessions and area treated — book a consultation for an exact quote. (Cost figures to be confirmed by the clinic before publishing.)

Which one is right for you?

• Choose Rejuran if your skin is sensitive, red, easily irritated, recovering from acne or laser, or simply looks tired and rough in texture — Rejuran’s PDRN is the repair-and-calm specialist of the three and is especially well studied for reactive, richly-pigmented skin.
• Choose Profhilo if you are in your mid-30s or beyond and your main concern is firmness — softening cheeks, a loss of bounce, fine crepiness, or that early “deflated” feeling — and you want overall remodelling rather than just surface hydration.
• Choose Skinvive if your skin looks dull and dehydrated and you want fast, natural-looking glow with minimal fuss — it is the gentlest option, has the quickest visible payoff, and is an excellent first skin booster.
• Consider combining (see below) if you want repair, firmness and glow — layering these in stages can give a more complete result than any single product delivers.

Rejuran Healer: the repair specialist

Rejuran Healer is built around PDRN (polydeoxyribonucleotide) — a polynucleotide fraction purified from salmon DNA. Unlike the other two boosters, Rejuran is not primarily a hydrator; it is a regenerative treatment that works at the level of the skin cell itself.

• How it works: PDRN activates adenosine A2A receptors, supporting DNA repair and cell renewal, calming inflammation, and prompting fibroblasts to lay down new collagen over the following weeks.
• Best for: a damaged skin barrier, persistent sensitivity or redness, post-acne and post-procedure repair, fine lines, and overall rough texture. Its anti-inflammatory action is one reason polynucleotide treatments are so widely used in Korean, Japanese and Singaporean dermatology, and why they suit more reactive, pigment-prone skin.
• What it feels like: a series of tiny intradermal micro-injections (or micro-needling delivery). Numbing cream is used; most people find it very manageable, with brief stinging at each point.
• Downtime & results: small bumps and mild redness can last a day or two. You typically notice texture improving from about two weeks, with the fuller effect after a base course of 3–4 sessions spaced 2–4 weeks apart. Results generally last around six months before maintenance.

Profhilo: the firmness remodeller

Profhilo, made by the Italian pharmaceutical company IBSA, is a striking departure from a normal filler. It is an ultra-pure, high-concentration (64 mg / 2 ml), non-cross-linked hyaluronic acid that spreads through the tissue after injection instead of staying put at the injection point. That is the whole point: Profhilo does not add shape or volume — it bio-remodels the skin.

• How it works: conventional fillers use heavily cross-linked HA to hold structure. Profhilo keeps HA in a more natural form, combining high and low molecular-weight HA to deeply hydrate while stimulating multiple types of collagen and elastin — improving firmness and that “deflated” quality over time.
• Best for: skin laxity and loss of elasticity, an overall softening or “draping” of the lower face, and patients (usually from the mid-30s) who want to improve the skin’s framework rather than fill a specific area.
• What it feels like: a major comfort advantage is that only five injection points per side are used (the BAP, or Bio Aesthetic Points, protocol), so there are far fewer needle entries than a typical mesotherapy session.
• Downtime & results: small raised “blebs” at the injection points usually settle within about a day. The standard course is two sessions four weeks apart; visible change often starts around four weeks, with the fuller effect by 6–8 weeks. Results last roughly six months, with maintenance suggested every six months.

SKINVIVE by Juvéderm: the glow booster

SKINVIVE is part of the Juvéderm family from Allergan, but it is not a contouring filler. It is a lightly cross-linked hyaluronic acid combined with mannitol (an antioxidant that slows HA breakdown and helps reduce swelling), designed purely to improve the skin’s inner hydration and surface glow.

• How it works: tiny micro-droplets are placed evenly in the upper dermis (a mesotherapy-style technique), forming small hydration reservoirs throughout the skin. The result is smoother, more luminous skin without any visible lumps or surface change.
• Best for: dull, dehydrated, lacklustre skin; anyone chasing a natural “glass-skin” glow; and first-timers who want a low-commitment introduction to skin boosters. It improves radiance noticeably on the slightly sallow or tired-looking skin many of our patients describe.
• What it feels like: the gentlest of the three. With numbing cream, most patients describe brief, light pinches across the cheeks.
• Downtime & results: minimal — small bumps may be present for up to 24 hours. Many people see glow within days, with the result peaking around a month and lasting roughly six months. It is often the highest “instant satisfaction” option of the three.

Note: Dr. Dan Xu is an official Allergan/Juvéderm trainer in North America, which means our Markham clinic works closely with the Juvéderm portfolio, including SKINVIVE, and trains other injectors on it.

Can you combine them?

Yes — and for many faces a staged combination gives the most complete result, because each product solves a different problem. A common strategy is to repair first with Rejuran to settle the barrier and calm sensitivity, remodel with Profhilo to rebuild collagen and firmness, then finish with Skinvive to lock in hydration and glow. These are usually done on separate days (and not stacked in the same spot on the same day), in an order tailored to your skin. Because their mechanisms are complementary rather than redundant, the layered effect is often better than any single booster alone. The right protocol depends entirely on your skin, which is what an in-person assessment is for.

Who is not a good candidate?

These are safe, well-studied treatments, but they are not for everyone. You may need to wait or choose a different option if you:

• are pregnant or breastfeeding;
• have an active skin infection, cold sore, open wound, or active acne breakout in the treatment area;
• have a known allergy to hyaluronic acid, lidocaine, or — for Rejuran specifically — to fish/salmon or seafood (tell your physician);
• have a history of keloid or hypertrophic scarring;
• have a bleeding disorder or are taking blood-thinning medication (this raises bruising risk and must be reviewed);
• have an autoimmune or active inflammatory condition, or are immunosuppressed;
• have recently had, or plan to have, another injectable, laser or energy treatment in the same area — timing should be coordinated by your physician.

This is general information, not medical advice — a qualified physician should confirm your suitability in person.

What results should you realistically expect?

Skin boosters improve skin quality — hydration, texture, glow, and firmness — but they do not reshape your face, fill deep folds, or replace a filler, Botox, or an energy-based lifting device. They work gradually as your own skin responds, so the meaningful result builds over weeks rather than appearing the moment you leave the clinic (Skinvive’s glow being the quickest to show). All three are also maintenance treatments: results typically last around six months, after which a top-up keeps the improvement going. Honest expectations are the biggest predictor of satisfaction — which is why we would rather tell you that a different treatment suits your goal than oversell a booster.

How much do they cost in Toronto?

Cost depends on the product, the number of sessions in your course, and the area treated. As a general guide:

(Exact ID Cosmetic Clinic pricing to be inserted before publishing.) Be cautious of prices well below market — for injectables, an unusually low quote can mean a counterfeit or diluted product, or an unlicensed injector. Always confirm you are receiving genuine, physician-administered product.

Why choose ID Cosmetic Clinic for skin boosters?

Injectable skin boosters are only as good as the physician choosing and placing them. At ID Cosmetic Clinic in Markham, every skin-booster plan is led by Dr. Dan Xu, M.D., CCFP — a CPSO Licensed Physician, official Allergan/Juvéderm trainer in North America, Clinical Preceptor at McMaster University’s Medical Program, and Founder & Medical Director of the clinic since 2017, with 8+ years and 5,000 clients · 80,000 treatment areas of experience. Our practice primarily serves Asian faces, and we select and sequence boosters accordingly — Profhilo’s remodelling and Skinvive’s glow — to suit more reactive, pigment-prone skin.

Related at ID Cosmetic Clinic

• Treatment: Salmon Meso (PDRN) · Profhilo · SKINVIVE by Juvéderm · Skin Boosters overview
• Concern: Dull & dehydrated skin · Early skin laxity
• Learn: What is a skin booster? · Skinvive vs dermal filler